classwork/Homework
Monday IB Biology - so today we started by watching the following video. https://www.youtube.com/watch?v=zeIsxXDyjlc While this isn't a requirement, you could earn extra credit by creating a pedigree for this bizarre family situation. Next, we looked at all of the AI topics that have been done in the past to develop some usable ideas that interest us. These are only foundations for you to build on, but please come tomorrow with 1 or 2 ideas for possible IAs. We'll be sharing these ideas. https://www.nuffieldfoundation.org/practical-biology/environment https://www.sciencecourseware.org/BLOL/ https://ibbetter.com/biology-ia-ideas/ https://www.humanbenchmark.com/ Lastly, you worked on your presentations on genetics. Be sure that you come to me with any questionable material as you are meant to be an expert on these topics, which are mostly review from your earlier biology course. Resident Leadership Academy (RLA) Will be starting in the spring!!! Do you need to get an internship in? No worries, sign up for RLA. Please follow this link RLA Information for more information and to apply. There are a limited number of students accepted so don't delay. Honors Biology - OH I ALMOST FORGOT, Get your parent Input. Don't forget: Score, Signature, Comment https://media.hhmi.org/biointeractive/click/CRISPR/ Walk through the interactive first (How it Works tab), and then... Watch the following videos (How it is Used tab) about cancer and DMD 1st video and the next four clips from Dr. Neville Sanjana - 4 clips and lastly, the next four clips from Dr. Amy Wagers - 4 clips Summarize the nine clips into a paragraph (It should have three major ideas from the videos). We will use that tomorrow. HEY! If you are interested in science UCSD has a summer program called COSMOS. I've attached the informational flyer as a file below. Check it out. It is a residential program and costs money, BUT IF YOU CAN'T AFFORD IT, THEY MAY JUST IGNORE THE FEES FOR YOU!!! At least check out the flyer! Tuesday IB Biology - Today we reviewed your IA topic and guided you towards writing a testable question. Please come tomorrow with a solid research question. A solid research question should have clearly identified goals, clear variables, and is practical to carry out. Next we reviewed the chi-squared test for those who were absent, but at this point you should all be ready to role in presenting. Remember, I will ask you about a topic and you will discuss the topic in the context of your genetic disorder...or how it doesn't pertain to your disorder. To help facilitate this process, please make sure that you have shared your presentation with me at [email protected]. Lastly, know that you will be graded using the Criterion A rubric. Honors Biology - Today we spent much of our time really bringing the big idea of genetics to a close. We then spent a good chunk of our time describing how the Final Project/Exam would work. I've posted this criteria below as a downloadable file. IN addition to coming in with a game idea and knowing your lowest two criterion scores, I also want you to not forget to get your parent Input sheet signed. Don't forget: Score, Signature, Comment. I will be checking these off starting tomorrow. Wednesday IB Biology - Today we started our presentations. For those of you who showed up, it was a very simple process where I work as your partner. Your sole job is to make sure to know how our content relates to your topic. SO what do you do tonight if you are finished?! You will formallize the research question with me by turning it in tomorrow. What else should we do? ...probably be aware that we will be having pet day. This is a pet day where you can bring it in and share your pet during your period. Please be aware that the organism needs to leave campus afterwards. I can stash small animals and plants here until the end of the day. Lastly, you will submit the pictures and measurements for your pet on Friday for extra credit. The amount is dependent on the quality of the work you have done. Honors Biology - Today you started by learning about PIG-MONKEYS!!!! ...and then you dove into the game you are developing for your final. We clarified each of the criterion in what can be used for your project and it seems like most of you are really "running" with it! Tomorrow you should start laying this game out so understand that you should have a solid idea of what you are doing before tomorrow. I'll be looking for construction. You should also be aware that Friday will then be the last class day to work on your game. You'll have the weekend, but we will test the games on Monday. It may seem like you have a lot of time, but you don't really. You have just enough time. If you haven't done it yet, don't forget to get your parent Input. Don't forget: Score, Signature, Comment Thursday IB Biology - Today we continued our work on genetics. Tomorrow though we will be... Taking our last day to finish you all up We will get a chance to look at your extra credit pet project and prepare for our final. Please make sure you are fully ready. Honors Biology - Tomorrow will be our last day to work on your games. At this point in time you should just be developing questions as you should have the physical game built by tonight. On Monday you will be testing the games out. Before we get to Monday, please make sure that you check all of the criteria on the IB Grading Rubric. Tomorrow is also your last day to turn in the parent Input. Don't forget: Score, Signature, Comment. Friday IB Biology - Please come on Monday prepared with any questions. We will prepare for finals. Spend some time to the materials. ...Seriously. No, Seriously. Honors Biology - Parent Input is due today! On Monday there is only one thing you need, your game. You must have it.
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Monday
IB Biology - The following topics are concepts that should be included in your genetic disorder project. These topics are coming from chapters 3.3, 10.1, 3.4, and 10.2. You should understand each of these and be able to describe how they relate to your disorder. Yes, this is like a report, but know that you will have to present these topics to the class in the context of your disorder. Meiosis Homologous Sister chromatids Chiasmata formation Crossover Independent assortment Problems with haploid diploid cells. Non-disjunction. Polyploidy cells Methods of karyotyping sampling and risks. Mendel Alleles Dominant Recessive Codominant Sex Linked/linked Polygenic traits Pedigrees Punnett squares Here's a great video to give you the basics of the material in 3.3 and 10.1. PLease watch this and then come prepared with questions: https://www.youtube.com/watch?v=c5hA0WCv1lg Honors Biology - https://ourworldindata.org/cancer 1) Look at the world wide data and look for trends that have happened in the world over time. Write these in your notebook on the right. 2) Now identify those diseases that are cancer related. How do those trends change over time? Write these down on the right side of your notebook. 3)Now go into your lab group and each of you should select a different country each from different continents (North America, South America, Europe, Africa, Asia, Australia). Pick a common cancer disease and see how the trends have varied in each of these regions. Write down your findings in your notebook on the right hand side. Tuesday IB Biology - Here's a good video on meiosis disorders, watch this: https://www.youtube.com/watch?v=iXjCg_2vZQs Come prepared with any questions you might have. Please also complete the DBQ on page 167, ready to be turned in. Here's the presentation on 10.1 from today if you would like to review it. I only didn't get through Mendel and his idea of independent assortment: https://www.bioknowledgy.info/101-meiosis.html What you should have at his point is a genetic disorder which has been described completely and you are now trying to describe the specifics of how it functions and is created. You should be able to utilize all of the terms placed on Monday, and now be able to describe how meiosis plays a role (or not) in your chosen condition. Applications you should be familiar with: 3.1
10.1 NONE Honors Biology - Please look at the image we saw in class, click the link below. On the right side of a new entry titled, "Cancer Cell Invasion", please make a sketch of the image (including color), print up or write the explanation of what is happening, and be sure to define what a "leader cell" is, and what "metastasize" means. https://www.biointeractive.org/sites/default/files/CancerCellInvasion-StudentHO-PI.pdf This is all you must do in preparation for tomorrow. Wednesday IB Biology - Today we looked at this power point and using it I would like you to come prepared with some practice punnett squares. The Punnett squares that you should know are listed below. This could be as simple as just copying them down, but make sure you understand them. If you are struggling, remember, "Be Like Reece" and come talk to me. So, to sum it up, complete the 5 punnett squares listed below under 3.4 and please also complete DBQ 183 3.4 basic inheritance: https://www.bioknowledgy.info/34-inheritance.html 3.4
Honors Biology - Cell Cycle and Cancer Click and Learn Activity https://media.hhmi.org/biointeractive/click/cellcycle/ Use this student handout: do as partners but produce one paper (each partner must alternate writing) https://www.biointeractive.org/sites/default/files/Cellcycle-Worksheet.pdf The major portions of the work fall into the following groupings: 1-9 Background 10-12 Cycles 13-19 Diagram 20-30 Extra Credit: 31-34 This work is all due tomorrow for a grade. Work well! Thursday IB Biology - Today we started by reviewing what we know and then headed into the big ideas of chapter 10.2. Of course, we didn't get far so we will continue this tomorrow, but you should preview the powerpoint I was using so you can come in educated, but with questions. Here is the link to that presentation: 10.2 Inheritance: https://www.bioknowledgy.info/102-inheritance.html Before tomorrow, before we start back in on the material, I would like you to create a simple dihybrid cross punnett square for any 2 characteristics you like. MAKE YOUR OWN CRAZY IDEAS. Ex. 2 Giraffe have an offspring with spiral horns vs no horns. Spiral horns is dominant. And stripes vs spots with spots being dominant. If they had 79 babies, how many of each type would they produce. Lastly, you should complete DBQ186 - Chernobyl SO do any of you want to go on a hike (with potential extra credit)? I could keep it closer to home than last time. Let me know if you have any interest tomorrow as I will be hiking again on Sunday. Honors Biology - So after talking about our unit exams from our last unit, we then turned in our work on cancerous cell cycles. After discussing those responses we watched the following video to get the big picture about what this looks like. https://www.biointeractive.org/classroom-resources/how-tumors-grow Next, I had you discuss with your shoulder partner what the five big ideas we should pull away from the activity and you write these down on the left side of the entry. Tonight I want you to write a cohesive paragraph using those ideas that EXPLAINS what the cell cycle has to do with cancerous tumors. I found this interesting article you might want to read (not required) : medicalxpress.com/news/2019-12-protein-cancer-suppresses-anti-tumor-immunity.html If you have any interest in going on a hike on Sunday with me and some seniors, please see the notice I placed under Thursday for my IB Course. Friday IB Biology - SO today we used your homework from last night to work out a sample of the Chi-Squared test. This will be a good example to work from as we prepare for your presentations next week. The following list are all of the topics that you should be able to present about in context to your genetic disorder. Remember, that you will have Monday and Tuesday to prepare and ask questions. Crossover Independent assortment Sex linkage (or any) Morgan’s fruit flies Non-disjunction Dominant, recessive, and codominant Dihybrid punnett squares Discrete vs continuous variation Polygenic traits Chi-Square Test Honors Biology - Today we had a great Karaoke Friday, but then discussed what we understand about the cell cycle disruptions involved in cancers. P53 seems to be a very important regulatory protein and that's why we then went and attacked the following work with a new partner. You and your partner should be able to turn in your responses on Monday. Not many scores left before final grades. Work Sheet https://www.biointeractive.org/sites/default/files/p53_Worksheet_Overview_Final.pdf Role of p53 in the Cell Cycle interactive https://media.hhmi.org/biointeractive/click/p53/01.html ...MMMMonday IB Biology - Today we spent our time reviewing everything we need for the final lab report which is due tomorrow. What I failed to to do a good job of is dealing with uncertainty in measurement and use of error bars. I will be happy to work on these tomorrow if that would help. SO, your labs will not be completed and printed, and turned in until Wednesday! ...you can thank me later. IN the meantime, we will still be turning in your genetics work on the video from last week with one last connection... Knowing what you do about protein synthesis, what are the advantages and disadvantages to prokaryotes and eukaryotes processes in genetic transfer. You should should read chapters 3.1 and 3.2 and you should find your answers there. Hiker Extra Credit: If you went hiking with Karen and I this weekend you collected four plant samples (black oak, sugar bush, white sage, and buckwheat flowers). WHile three of these samples are leaves, the other is a flower, and so have different functions. Yet, it is important to notice that all of these plants live in the same environment and survive using similar and different strategies. Outline the adaptations that help these plants survive now. Next, Citing parts of chapter 5 from your book, please describe the role of natural selection in the plants, both currently and in past generations. Last, find out the water, sunlight, and resource thresholds for these plants, research the projected climate change for the region in 2050, and then decide on the survivability of this plant in the future. This should be a quantifiable study. You do not have to do all of these three things, but they are progressively more difficult. Also , just in case you are interested, are some of the summer opportunities for Rady's Children's Hospital. They are not free though. I know most of you will be looking at heading off to college, but I thought it might be something that looks interesting to you. : http://sdhealthscholars.org/about-medical-academy/ Honors Biology - So today, I would like to start out with a though for the day, "Don't regret your mistakes. You'll always make mistakes. The better you are, the less mistakes you will make. The only way to get better is to thoroughly analyze your mistakes." - Jame Altucher As we prepare for our final exam on this unit I want you to prepare one sticky note, index card, or scrap of paper. On this paper/card/note I want you to think about the above quote and to think about one (at least) mistake you have made in this class and write this on the note. Now, fold the note in half so no one can see your mistake, and on the outside give me your name and in one sentence tell me who you would like to be as a person. Only 1 sentence on your sticky note, no more ...that would be a mistake. :) You will turn this in to me tomorrow. In addition to the short work above, I want you to go through your notebooks and highlight the following terms and be familiar with what they mean. If you can't find one of them, be sure to add it to an appropriate place in your notes.
Tuesday IB Biology - First, make sure your lab is complete and ready to go Second, make sure you have your homework from the last few days ready to go. Third, make sure you have read the material in chapters 3.1 and 3.2 Last, Make sure to bring rain gear tomorrow! Honors Biology - First, Now let’s look at the big picture. Do you know these topics? You should have a basic understanding of these so that you can speak to them on your unit exam/case study. Unit 1
Lastly, as you look at this website, here are the first three questions to what you will need to address in your case study/exam.. Be sure you write down your research on the entry we started today.1) What is the background of your case? What is the condition, when does it occur, what are the symptoms, etc.? 2) How is DNA involved with this case, and if DNA code for proteins, how are proteins involved? 3)What role does mitosis and meiosis play in the case? Wednesday IB Biology - Tonight I want you to do two things, make sure you have read 3.1 and 3.2, and I would like you to select a genetic disorder that you can work on for your upcoming chapters. This disorder can be from this list, or any other place. https://www.genome.gov/For-Patients-and-Families/Genetic-Disorders The important thing is to understand the condition, symptoms, origins, etc. Honors Biology - SO today we worked on the first part of the your unit exam. This part was a graphic organizer that discussed how normal inheritance can be disrupted by genetic issues. If you want to clean it up tonight, you can, but don't forget to bring it to school. The next thing you should do is to look at the following questions that you need to respond to about your genetic condition. These should be added to your notes for use tomorrow.4) How/where/when did the error in the DNA occur? Meiosis (crossover, nondisjunction), etc. 5) Can you use statistics to describe your case? Make a Punnett square, create/use a fictional pedigree, or describe why these tools can't be used. I need to only see that you understand the basics so if you have a very complex genetic issue, just come up with a simplified version. 6) How does this condition affect the disruption of feedback or homeostasis? Tomorrow you will have the opportunity to work with the last 2 questions and clean up your work from today and tonight. Thursday IB Biology - Today we had a chance to walk through the material in chapters 3.1 and 3.2, and I SWEAR you will take the quiz on this chapter tomorrow. ...Yes, it is a minimum day. Also do not fail to bring your homework. In addition, I want you to complete the DBQ found on page 145. This will be turned in tomorrow as well. Lastly, I want you to think about your PETS!!! Have you taken a mass measurement and picture? WHat else has changed about your pet? Think behaviorally as well physically. We'll be turning a write up on the pet a week or 2 after thanksgiving. OH, and don't forget that we have an Adopted Family for the holidays this year! Please look at the pictures below to know what these family members Honors Biology - So at this point in time you have done quite a few piece of work on your final exam case study. 1) You should have a completed graphic organizer that shows stability and change in your body and how you can get the condition. 2) You should have clear and concise (to the point) to questions 1-6 (Punnett squares and pedigrees included) all clearly separated on a paper (or 2) that is NOT your graphic organizer. 3) Lastly, you will have another sheet that will address the following questions. 7) What are some ethical concerns about the current treatment of this condition, and future applications of CRISPR? 8) Create a personal reflection on genetics. What does it make you think of when you think about, how genes are passed on, on the future of genetics, on the future of genetic treatment of your case, ethics in treating genetic disorders. Tell me what scares or excites you? This is the free response that will show me that you've though about these topics beyond the classroom. This DOES have room for your personal feelings, but be sure you have clear reasoning! Bring it all together! Remember that you should be clear and concise (to the point), longer does not mean better. You should have them in order. Yes, you will have time to work on it in class tomorrow, but it is a minimum day. Final product turned in tomorrow. List, describe, EXPLAIN ...is the key! OH, and don't forget that we have an Adopted Family for the holidays this year! Please look at the pictures below to know what these family members Friday IB Biology - Other than don't forget to take your pet picture and record mass, etc. I want you to relax, get caught up on sleep, become unsick, and be very very thankful for the life you have and for the people who support you. As you look ahead towards December and maybe start to shop, please don't forget about our adopt a family. Their requests are posted below. Just click the pictures to see the detail, and you'll see they aren't asking for much. If you're in a situation where you can't donate, please don't feel pressured to, but even spare change can make a difference. Honors Biology - You guys have worked very hard in your first semester in high school. While you aren't quite done with the semester, I want you to reflect on your work this far, get caught up on your sleep, but most of all I want you to be thankful for the life you have - you are an amazing part of this universe - and be very thankful for all of those people around you who support you. As you look ahead towards December and maybe start to shop, please don't forget about our adopt a family. Their requests are posted below. Just click the pictures to see the detail, and you'll see they aren't asking for much. If you're in a situation where you can't donate, please don't feel pressured to, but even spare change can make a difference. Tuesday
IB Biology - Today you began testing, but over the week you will all be at different stages. So....here are some things that you should do. 1) Collect your data and make sure it sufficient and placed into a Sheets document so we can thoroughly process it. 2) Watch the following video and write down of anything you notice about the people in the movie. There are many details that could be easy to overlook: https://drive.google.com/file/d/16dGisI4TnrZtAiBm_OMyK4SlNSTHKcWe/view?usp=sharing 3) This coming Sunday my wife and I will be hiking Vulcan Mountain. It is a 5-6 mile loop that is one of the best hikes in San Diego. The trailhead is found at 1107 Farmer Rd, Julian, CA 92036. Please be sure to bring plenty of water (1-2l/person)and some snacks, good tennis shoes or hiking shoes/boots, sunscreen, hats, etc. are also recommended. The trailhead is about 45 minutes from El Cajon. We will be at the gates at 8am. I will let you know about extra credit as we start up the mountain. Lastly, know that the last day to apply for the Borrego Health Clinic internship is the 15th! Get your paperwork in! See me for details. Honors Biology - Today you started hacking up liver samples and started the process of testing. Yet there were a couple of groups in each class who were not prepared. This means that you and your partner don't work/communicate/etc. very well together. Tomorrow is your very last day to collect data on your experiment. Knowing this, you should be ready to execute whatever procedures you have designed. DO not fail! Bring your materials and I will support you. In the meantime, today you picked up the prepared handouts for body systems. You now have a decent picture (except for 1) for every body system and you need to get each in at the right entry. Just cut them and glue them in. It took me about 3-4 minutes to do from start to finish. If you don't have these put in, do not expect to start the lab! Wednesday IB Biology - So last night you had a chance to look at the video. You made some detailed notes about what you observed. Tomorrow you have a guest speaker. Next week we'll discuss your observations, but next I need you to answer the following questions in relation to the video. 1) The various forms of a gene/trait are called alleles, what alleles have you seen in these patients and in normal people? 2) If we were to consider the population in the video as homogeneous, what do you notice about their condition? 3) What might be the role of protein synthesis in this condition. You don't need to know, just hypothesize a few biochemical possibilities. ... Think globular and structural. Add your responses to the bottom of your notes. Honors Biology - Yes, today was a real success as people started to close their research and learn something! Tomorrow we will start to process your information so make sure that all of your numbers are in a Sheets doc. ...and know what your numbers mean for when I call on you! Thursday IB Biology - So tomorrow will be the last day for your investigation. Some of your data has been very clear and others' not so much. Regardless, we will continue to move on. The trait the the kids have in the video you watched is known as a sex linked trait because it is linked to the sex chromosomes. Most traits are are autosomal traits. Below the work that you you have completed already, please be sure to describe what these two ideas mean and then describe how a trait is passed on from parents to child by discussing the transfer of traits on chromosomes. Be specific and include meiosis, crossover, haploid and diploid cells, then discuss how mitosis would continue this propagation of a trait through the developing embryo. This work should be added to the video notes, and question responses. Remember, "list, describe, EXPLAIN" is the key to getting a good grade. Honors Biology - The goal for today is to take the data issues from today and be sure to avoid them in your data. Here are some things to keep in mind. 1) Bar or line graph? 2) Do you have a Title on your graph? 3) Do the two axes have labels AND units? If you can present your work in one really clear graph you will be in good shape. Tomorrow we will also be working on your conclusions, (and the appendix if applicable) so you need to get a rough draft completed with your partner. Just use the guide you have in your notebook, but please take a look at your data and see if you can explain what you are seeing. This is the first and second part of your conclusion. The third part you should rough draft is the evaluations and improvements. Did you make mistakes, is the data reliable? What would make this experiment more solid? Talk to your partner tonight and make sure you have at least rough drafted your important points for discussion tomorrow. Friday IB Biology - Today was your day to complete the work from this week. After three days we should have some results and can complete the last pieces of your report. The expectation for Monday is that you have completed all Rf values (probably averaged those as well for accuracy sake), run a validity test on the data, and then placed the essential information into a graph(s) that sums up your work nicely. In addition, once you have "boiled down" the data, you should be able to write a conclusion. If you want an improved lab report guideline, please check my website under "Online Resources" where a revised guide can be found on the right as a downloadable document. So Monday we should have a very nice piece of work to look at. You will only need one document per partnership, but don't print yet. We'll do that when we get through Monday. Reminder: This Sunday my wife and I will be hiking Vulcan Mountain. It is a 5-6 mile loop that is one of the best hikes in San Diego. The trailhead is found at 1107 Farmer Rd, Julian, CA 92036. Please be sure to bring plenty of water (1-2l/person)and some snacks. The trailhead is about 45 minutes from El Cajon. We will be at the gates at 8am. I will let you know about extra credit as we start up the mountain. Honors Biology - Today, I'll be honest, I was a bit concerned about some of the results of your research, so let me reiterate what you need. Actually it isn't the results, but the understanding of the results. 1) First, If you want an improved lab report guideline, please check my website under "Online Resources" where a revised guide can be found on the right as a downloadable document. Use this like a checklist for your lab and it will be perfect! 2) Most of you have done a great job of setting up the lab and finding out what you could investigate. So we'll focus on the tougher stuff, but don't forget the ABSTRACT. 3) On your graph(s), please present the data as a graph that pertains to your research aim. If the aim says, "...The denaturing effects of pH on catalase..." then your graph better be about exactly that, pH and the effects (bubbles). 4) Don't forget that all graphs should have a proper Title, labels, and units. Titles are made from the IV and DV. Labels are whatever your DV and IV are. The units are whatever you measured in (m, l, g, degrees, etc.) 5) As you write your conclusion, do NOT forget to connect your research to a real life application (like it says in your guidelines). 6) Your final copy must be presented in the order your guidelines say. Your spreadsheet work is NOT a separate sheet added at the end. You should "cut and paste" the spreadsheet and the graph directly into your document. 7) Lastly, you only need one copy for your group. You only need one, but it must be a HARD COPY! Don't ask me to print it, or everyone in your group will be poked in the eye with a sharp stick! Monday IB Biology - Today I only saw period 1, so we have two different things that need to happen depending on your class. IF you are in period 1, tomorrow we will start to look at your next formal lab on chromatography. Please bring your last formal lab, in any format, so we can see what we can improve upon this next lab, and you should also have some ideas about what you would like to do with your latest research. If you haven't been keeping up, here are some websites that will help you: https://www.chemguide.co.uk/analysis/chromatography/paper.html https://www.explainthatstuff.com/chromatography.html Plus, don't forget that your homework from last week was about finding out how chromatography is used in real life. Look back if you don't remember as you will need to have a real reason for the research you conduct. If you are in period 2, you will be completing the second part of your exam tomorrow and then working on your next formal lab, like period 1, so read the earlier description after preparing for the exam. Honors Biology - Today we looked at your genetic disorder homework, and then started the first part of your next formal lab. Here are the instructions from what we did today: 1. Place 2 ml of the 3% hydrogen peroxide solution into a clean test tube. 2. Using forceps and scissors cut a small piece of liver and add it to the test tube. Push it into the hydrogen peroxide with a stirring rod. Observe the bubbles. What gas is being released? (consider the equation) ______________________ Throughout this investigation you will estimate the rate of the reaction (how rapidly the solution bubbles) on a scale of 0-5 (0=no reaction, 1=slow, ..... 5= very fast). This is very subjective, but assume that the reaction in step 2 proceeded at a rate of "4" Recall that a reaction that absorbs heat is endothermic; a reaction that gives off heat is exothermic. This is now our control, or baseline data for comparisons. 3. Now, feel the temperature of the test tube with your hand. Has it gotten warmer or colder ___________ Is the reaction endothermic or exothermic? ___________ 4. Pour off the liquid into a second test tube. Assuming the reaction is complete. What is this liquid composed of (consider the equation again)? _______ 5. What do you think would happen if you added more liver to the liquid in the second test tube? _____ Test this and record the reaction rate. Reaction Rate ___________ (0 – 5) 6. Add another 2 ml of hydrogen peroxide to the liver remaining in the first test tube. What is the reaction rate? ________ 7. Now that you have completed your test, Is catalase reusable? Explain how you know. You will now test for the presence of catalase in tissues other than liver.
2) An idea of what kinds of environmental change you would like to investigate with enzyme function. (pH, hot temperatures, cold temperatures, UV exposure, altitude, hydration, etc.) 3) Using your lab write-up guidelines create your research aim, write your background information (on enzymes, why you want to investigate what you do, how is it like real life, etc.), and a hypothesis with an explanation. 4) You should also know how to measure changes in enzyme activity. (Just like the liver test maybe?) If you come unprepared, you will not be working with your lab group. Tuesday IB Biology - The SDSUS School of Nursing Sign Up on November 2oth is now open to sign ups. Today our main goal was for you to understand chromatography and its many applications. We then looked at possible avenues for research (and there's a lot)! When I see you next, I need you to be prepared with a research aim that you collaboratively work out with your partner (if you have one). We will next review our old lab reports on enzymes to improve on our experimentation and then commence our research. Here's the interesting professional website I found on chromatography: https://www.chromatographytoday.com/news/gc-mdgc/32/breaking-news/chromatography-is-a-breath-of-fresh-air-for-drug-testing/34018 Honors Biology - See the instructions posted from yesterday. ** If you are really interested in genetics (the topic we are studying), please check out this article. If you are REALLY into this science, tell me in detail how this condition is like and not like DMD and I'll give you extra credit. If it isn't detailed (evident that you read and understand), no credit for you. https://www.nytimes.com/2019/11/04/health/alzheimers-treatment-genetics.html?auth=login-email&login=email&utm_source=Global+Health+NOW+Main+List&utm_campaign=999059a655-EMAIL_CAMPAIGN_2019_11_04_07_11&utm_medium=email&utm_term=0_8d0d062dbd-999059a655-2841569 Wednesday IB Biology - You job is to make sure that you have a properly developed lab procedure. If you signed up for the field trip on the 20th for SDSU Nursing, please either pick up your permission slip, or return the slip to me. Honors Biology - The only thing that you need to do is to get your lab planned out with your partner. So, this means that you should have pretty clean rough drafts of the Title Page and Design sections of the lab and all of the sub components. Do NOT come in unprepared! Thursday IB Biology - Today we worked really hard to make sure that we have our lab lined up and ready to go for Friday/Tuesday. If you are not familiar with how the experiment can be fully executed, please be sure to review the previous websites that will tell you in detail how this happens. IN fact, if you don't "get it", you can't write good procedures. You should have what you need, as well as a detail procedure. While you are getting work done, consider this program. It is NOT cheap, but I think it doesn't hurt to offer it here. Sometimes these programs have scholarships too. See the flyer I've attached below for more information. My name is Nicole Givenrod and I am the Program Director for the UC Irvine Health Department of Urology’s Summer Surgery Program. I’m excited to share that applications for the 2020 Summer Surgery Program are now available! The program offers 2 session each lasting 2 weeks each. Session I: July 6, 2020 – July 17, 2020 and Second Session II: July 20, 2020 – July 31, 2020. Applications are accepted until the program is full and we do offer scholarships. Please be advised the scholarship applications are due by April 1, 2020. I was hoping you could pass the information on your students. I have attached a flyer with details regarding the program and the link for the Summer Surgery Program below. If you or any of your students have any questions please feel free to email or call me. http://www.urology.uci.edu/education_summersurgery.shtml Thank you in advance for your willingness to send this out! Sincerely, Nicole Givenrod | Summer Surgery Program Director Department of Urology | UC Irvine Health 333 City Blvd. West, Suite 2100, Orange, CA 92868 Office: 714.456.6047 | Fax: 1.888.378.4358 [email protected] Honors Biology - YOu should be ready to experiment on Tuesday, but that's because we will make sure your lab is cleaned up tomorrow and that you have all of your equipment. Please be ready with a CLEAN rough draft of your research. Friday IB Biology - Hey, please help out David Parra with his EE research and fill out the simple survey so he can collect data. You all know how important data is to much of the work you do. LInk: https://docs.google.com/forms/d/e/1FAIpQLSfYEpJ2QtUIZfwkEV96X0TVYDoTLw70gDR5UCFd2MSqU6dB8w/viewform?usp=sf_link In addition to David's survey, please be sure to be ready for experimentation first thing on Tuesday. Remember that each day next week we will be an introduction to the genetics we need to cover as well. Honors Biology - Today we focused on a number of things that are fine points to consider while developing your final lab procedures. 1) Use the term "denature" to indicate change in the enzyme, 2) Catalase is the name of the enzyme you are working with. 3) Be sure that you are specific in your amounts. 4) Make sure the amounts you have selected easily fit into a test tube. 5) YOu actually know what you are doing. 6) When this is all done, you should have a picture or illustration of your procedures and set up. This can be done now with an illustration, or you can take pictures to use when you produce your final lab report. When you come back on Tuesday, please understand that the expectation is that you have clear direction and can begin working. I will be out of town most of this weekend so I may not be available for questions.
Monday
IB Biology - Academy Awards Link: https://docs.google.com/forms/d/e/1FAIpQLScQKUJ_YAv_TqWLRYU7zWkqk_IRh-cIwC6EBqfjHnaTXhN2rg/viewform?usp=sf_link Please also start the preparation for the unit exam, by reviewing chapters 2.1-2.6, 7.1-7.3, and 8.1. Of course, most of what we have done is on chapter 7 so spend some time and get ready to ask serious questions. Figure out which questions you are still confused about? Go over all of the understandings, skills, and applications. We'll go over these starting tomorrow in preparation for a test on Wednesday and Thursday. Honors Biology - Today we started by talking about how plants can reproduce is a number of ways and then I offered up clones of my succulents from home. If you want one, but didn't get one, let me know and I'll find you some next weekend. Next we quizzed you on your ability to do a simple punnett square for 2 given parents. It's pretty clear you either get or you don't. So far, everyone I've talked to about low grades did not complete their work from last week. Lesson learned! If you do have this work completed, come see me at lunch and we can review and do a make up. Lastly, you completed a self-assessment for your genotype and phenotype. It's really important that you come prepared with this work tomorrow since you will be paired up tomorrow with another person to make a baby! Tuesday IB Biology - Today we took time to slowly walk through the complex processes of protein synthesis. Like last night you should consider reviewing your work so that we can answer last minute questions. If I were you, I would literally walk through the Understandings, Skills, and Applications and quiz yourself. The academy awards have been decided, but I somehow missed out on three of the videos. Please feel free to watch these videos that you haven't seen. https://www.youtube.com/watch?v=cMwFz4-UbJ8 https://www.youtube.com/watch?v=lRykqjt7W-M And the last one is a file at the end of this blog post. ...it's too big for me to upload, sorry. Honors Biology - SO today we spent looking at your quizzes. For most of you, you either knew it or you didn't. Regardless we added the sex linked trait of DMD and showed WHY it's a disfunction found nearly always in males. This is a key piece of information. Next we jumped into making a baby with a partner. Your job was to combine the genes and tonight you need to draw your baby. This should have been mostly done in class and don't worry about being an artist. But tonight you need to complete two other things as well: 1) Get your parent Input for your notebook, and 2) I want you to return to your entry on the muscle system and add a good quality picture of the muscular system. You can print this up or draw it, but make it look good. Wednesday IB Biology - FIRST, as a reminder, are you logging your volunteer hours, job shadows, and internships on the medpath website? Please remember if you want to finish our program, you must have : Job Shadow-Completed, and a Senior Exploration (Internship or 1-year hospital volunteering)-approved by Medical Pathway Coordinator, CPR certification recommended, and of course, all of the coursework completed with a C or better. On a separate note, if you want to be recognized by the district pathway, here's what you need to do: https://sites.google.com/guhsd.net/ghdhealthpathways/completer-status The big difference in becoming a gold completer is mostly in having CPR certification. As to tonight, I'd love for you to think about your chemistry from the standpoint of food being integrated into your body. Think of it from the moment you start to chew food to the point where the broken down monomers are reconstructed into new proteins for you body. Imagine a piece of food being chewed, saliva excreted, amylase breaks down any carbs, traveling to the stomach where pepsin starts to break down the proteins, and then to the small intestines where lipase is released, etc. Can you tell the other end of this story? Can you talk about the monomers of the broken down food being incorporated into the cells? What happens next? How does new proteins get created? This should be good practice if you work at it. Don't forget to go through your flashcards too! You should be able to discuss each of those cards in relation to this digestion thought experiment! Your test will start on Friday and finish next week. The last thing I want you to know is that we have worked on biochemistry for 12 weeks and we're almost finished! What we need to do now is push towards our next formal lab report which deals with molecule size and the application of this concepts through the use of chromatography. Tonight I want you to submit to me on a seperate piece of paper, some application of chromatography in real life, industry, or ??? You only need to be able to explain your application in real life and how chromatography works to help us in some way. Oh, and give me a name of someone you would like to work with, or if you would like to work alone, and if there is someone you cannot work with. Honors Biology - First, we're getting ready for the final for this unit. What can we tell from the case study? Next, return to your entry from the beginning of the year that was on the endocrine system and add a good quality picture of this system. You can print this up or draw it, but make it look good Lastly, be sure to get parent input! Thursday IB Biology - Today was...empty. I know it's halloween so have a good time tonight because, theoretically, you are prepared for your test tomorrow. Honors Biology - Today you worked as a genetic counselor on case study #1. Tonight you will have fun. ...please make sure you already have your parent input completed as tomorrow is the last day to submit that. Friday IB Biology - So today you took care of part 1 of your final Protein Synthesis/Nucleic Acid exam. You will take part 2 next week on Monday/Tuesday (depends when I see you). Other than what you already know I would suggest looking at the following website on gel electrophoresis to answer any procedural questions: https://scienceprimer.com/gel-electrophoresis-overview Next week we will start working on your next formal lab! Honors Biology - So today we started by collecting up your parent input. Then we reviewed our case study from yesterday and then you partnered up. I then gave you copies of 2 more case studies and you and your partner did them individually. Then you came together to show each other what you found out, and so that your partner could double check you. Lastly, we checked the results out in class. This weekend, on the empty page near your first case study, I want you to research your own case study. Here are the criteria that you should include on the blank left page next to your first case study. Name of a genetic disorder (that is not one that we have examined): Background Info: What type of problem does the error come from? (mitosis/meiosis/mutation/inheritance/etc.) Is this problem dominant, or recessive, or sex linked? Make a fictional pedigree that is at least 3 generations Make a punnett square to describe the offspring of an afflicted person with someone who is not afflicted. Here's a website of disorders you could use, but be careful as some would be trickier to work with than others. https://www.healthdirect.gov.au/genetic-disorders Monday
IB Biology - Today we discussed epigenetics, and then went through all of the material for chapter 7. https://www.bioknowledgy.info/71-dna-structure-and-replication.html, https://www.bioknowledgy.info/72-transcription-and-gene-expression.html, https://www.bioknowledgy.info/73-translation.html Tonight I would like you to take your flashcards and to place them in an order. This order should be placed from start from finish. In other words, in protein synthesis, which term/concept should come first, and which comes next, and which is last. Lastly, you worked on the Video Production which should be done on Wednesday and will be viewed on Friday. FRIDAY is the Last day to pay for IB Exams Hey, don't forget that the 2021 trip to Spain will be meeting tomorrow night at 5:30 in room 32!!! Talk to your parents if you are interested. Honors Biology - Today you started by reviewing the homework by discussing the highlighting each person chose for their section of the article you were given on Friday. Next you got a page of visuals that went through the two major processes cells go through and we discussed the details of each in regards to the article. Tonight I want you to watch the following video and added notes to the diagram sheet I gave you today. Meiosis: https://www.youtube.com/watch?v=qCLmR9-YY7o ONE MORE THING, you may want o bring earbuds for the music on the simulations and videos you will be watching in the next 2 days. Tuesday IB Biology - The first thing I want you to do is to look at the order that you put your flashcards in with someone else. Compare what you did and what they did and discuss why you did things the way you did. Should some not be in the order at all? Why or why not? Once you have spent 10 minutes doing this, you may want to compile questions for me for when I return. Please spend the rest of the day working on your video production. FRIDAY is the Last day to pay for IB Exams Hey, don't forget that the 2021 trip to Spain will be meeting is TONIGHT at 5:30 in room 32!!! Talk to your parents if you are interested. Honors Biology - Today what you are going to be doing is to work with 2 other people (group of 3) and you will create a Venn Diagram that compares and contrasts mitosis and meiosis. This diagram should be rough drafted first on scratch paper, but your beautiful final copy should be transcribed underneath the diagrams on the left side of the entry from yesterday. Now, you will Start a new entry called "What are the chances of inheriting a trait?" I will need you to take notes on this simulation (link is below). The notes you take will go on the right hand side of this entry and you should find all of your information on these terms from the four phases of the simulation. Do not skip as you will be quizzed on your understanding of the vocabulary later in the week and need to know this stuff. Here are the terms: meiosis, fertilization and genetics, genes, alleles, chromosomes, phases of meiosis I and II (prophase, metaphase, anaphase and telophase), interphase, cytokinesis, homologous chromosomes, sister chromatids, fertilization, genetics, homozygous, heterozygous, genotype, phenotype https://www.biomanbio.com/GamesandLabs_old/Genegames/snurfle_meiosis_and_genetics.html Tonight I only need you to really know this material. Please quiz yourself as you will be quizzed on Friday. Wednesday IB Biology - This is your last class day to work on the video project. Tomorrow you will have a guest speaker. Work hard! FRIDAY is the Last day to pay for IB Exams Honors Biology - Today you will start by doing a genetics quiz online: https://biomanbio.com/HTML5Quizzes/genequizzes.html You can use your notebooks as you test yourself. Do you know your stuff? If not, be sure to spend some time pulling it all together. Quiz on Friday. Now go to the left hand side of your entry from yesterday where you defined all of those terms and now you will watch the following interactive Khan Academy Video: https://www.khanacademy.org/science/biology/classical-genetics/mendelian--genetics/v/introduction-to-heredity When you are done with this first introductory video, please record part 2 and record at least 3 examples(pure-bred parents, heterozygous parents, etc.) from this video in your notebook. Be sure to record notes on each of the punnett squares so you know what they are demonstrating: https://www.khanacademy.org/science/biology/classical-genetics/mendelian--genetics/v/punnett-square-fun You have just enough time to do this if you work quickly, but what doesn't get done, you will have to complete at home. You WILL have a quiz on the vocabulary (that was listed yesterday), and the use of punnett squares on Friday. You will not even be able to complete the quiz unless you know what I'm asking you by knowing the vocabulary!!!! Thursday IB Biology - Guest Speaker Jennifer Cochran is coming to speak with you. For today's speaker please know that the presentation is going to happen in Mrs. Hirt's room, right next door. As soon as the substitute teacher take attendance, head right over. Mrs. Hirt will be waiting for you. BEFORE Friday, I must have your storyboard as well as a link to your video, please share these with me. We will play all videos tomorrow. The categories you will vote on tomorrow are the following: Best Actor/Actress in a Leading Role, Best Supporting Actor/Actress, Best Make-Up/Costume/Hair Styling, Best Sound Track/Music, Best Visual Effects, Best Editing, Best Explanation of DNA, and Best Picture. FRIDAY is the Last day to pay for IB Exams Honors Biology - Guest Speaker Jennifer Cochran is coming to speak with you. For today's speaker please know that the presentation is going to happen in Mrs. Hirt's room, right next door. As soon as the substitute teacher take attendance, head right over. Mrs. Hirt will be waiting for you. Hey, hey, hey , hey....Quiz is tomorrow. You must know the vocabulary as well as how to use punnett squares. Friday IB Biology - So today, after all of your hard work, you got the chance to see the suits of your labor. Today I hope you put down some notes on who you thought might win each of the academy awards we'll be handing out. Here's the link, but don't use it until we've seen all of the movies. Academy Awards Voting Link: https://forms.gle/PrXVR4u67jbMD5LT9 You will only be able to vote once! Next week, after watching the last of the movies, we'll be going into preparation for our unit exam, and then into our next formal lab report. Be sure that if you still have lingering questions about these processes, you share them with me next week so I can answer them. Honors Biology - Well, most of our day was taken up with clarifying all of the material that you picked up, but maybe weren't very clear about, from the last few days. Then we worked towards our quiz. We clearly haven't answered all of our ideas about this topic so we will continue next week where you'll practice all of your genetic trait skills by making a baby! ...Yes, you can name them Brendan or Casey in my honor. Monday
IB Biology - Today we reviewed how we should approach TOKs in the future, and then checked off your flash cards for completion. Lastly, I gave you the criteria (A and D) for your project on protein synthesis (2.7, 7.1, 7.2 and 7.3). Tonight you need to go through all of your flashcards, but only once or twice. Make sure you are sticking those terms in your head. Second I need you to start a storyboard with your partners. A shared google slides presentation would work well. In the notes section you could make sure you account for everything you need to have in your presentation Honors Biology - Here's the link to the simulation we played with today. http://genes.inquiry-hub.net You should have started the process of understanding Protein Synthesis, but we still have a long way to go. From the steps you learned about today, I want you to watch the following video (https://www.youtube.com/watch?v=Vm3MWy3lY4Q) and write the narrative for what is going on in the video and how it matches the simulation that we played with today. In other words, add text to the observations we made in class. This goes on the bottom of the right hand page we started today. Tuesday IB Biology - So today is the first real work day for this project. and I have posted every bit of information you could possibly need to know for this movie below. Please cut and paste these into your google slides. You can move them around into your story board, but eventually you will share these with me so I can assess you work. I believe all of this will be due next Wednesday, but that may change as we get closer to the date. Tonight you should have a rough framework of your scenes and which standards they will address. The second thing I would suggest is that you take another run through your flash cards tonight. Don't forget about the old cards either as there will be questions on our second unit exam from the past. Lastly, I want you to start your outline of a criteria D project, a reflection on the use of CRISPR, Gene Therapy, and drug therapies that work on post transcription modification on people with genetic disorders such as DMD, or Cystic Fibrosis, or ??? This is a pro and con paper with your evaluation at the end. Be thorough in your discussion. No more than one sheet of paper front and back. This will be due on Thursday. Here's the criterion D top descriptor: The student is able to explain the ways in which science is applied and used to address a specific problem or issue, discuss and evaluate the implications of using science and its application to solve a specific problem or issue, interacting with a factor (moral, environmental, social, technological, ethical, historical), consistently apply scientific language to communicate understanding clearly and precisely, and document sources correctly. 7.1 DNA Structure and Replication Essential Idea: The structure of DNA is ideally suited to its function. U 1 Nucleosomes help to supercoil the DNA. U 2 DNA structure suggested a mechanism for DNA replication. U 3 DNA polymerases can only add nucleotides to the 3’ end of a primer. U 4-5 DNA replication is continuous on the leading strand and discontinuous on the lagging strand, and carried out by a complex system of enzymes. U 6 Some regions of DNA do not code for proteins but have other important functions. Such as ??? A 1 Rosalind Franklin and Maurice Wilkins’ investigation of DNA structures by X-ray diffraction. A 2 Use of nucleotides containing dideoxyrubonucleic acid to stop DNA replication in preparation of samples for base sequencing. A 3 Tandem repeats (VNTR) are used in DNA profiling. S 1 Analysis of results of the Hershey and Chase experiment providing evidence that DNA is the genetic material. NOS 1 Making careful observations-Rosalind Franklin’s X-ray diffraction provided crucial evidence that DNA is a double helix. 7.2 Transcription and Gene Expression Essential Idea: Information stored as a code in DNA is copied into mRNA. U 1 Transcription occurs in a 5’ to 3’ direction. U 2 Nucleosomes help to regulate transcription in eukaryotes. U 3 Eukaryotic cells modify mRNA after transcription. U 4 Splicing of mRNA increases the number of different proteins an organism can produce. U 5 Gene expression is regulated by proteins that bind to specific base sequences in DNA. U 6 The environment of a cell and of an organism has an impact on gene expression. A 1 The promoter as an example of non-coding DNA with a function. Or you could use Telomeres. S 1 Analysis of changes in the DNA methylation patterns. NOS 1 Noticing patterns, trends and discrepancies- there is mounting evidence that the environment can trigger heritable changes in epigenetic factors. 7.3 Translation Essential Idea: Information transferred from DNA to mRNA is translated into an amino acid sequence. U 1 Initiation of translation involves assembly of the components that carry out the process. U 2 Synthesis of the polypeptide involves a repeated cycle of events. U 3 Disassembly of the components follows termination of translation. U 4-5 Free ribosomes synthesize proteins primarily for secretion or use in lysosomes, and bound ribosomes synthesize proteins for use primarily within the cell. U 6 Translation can occur immediately after transcription in prokaryotes due to the absence of a nuclear membrane, but not in eukaryotes. U 7-10 The sequence and number of amino acids in the polypeptide is the primary structure. The secondary structure is the formation of alpha helices and beta pleated sheets stabilized by hydrogen bonding. The tertiary structure is the further folding of the polypeptide stabilized by interactions between R groups. The quaternary structure exists in proteins with more than one polypeptide chain. A 1 tRNA-activating enzymes illustrate enzyme-substrate specificity and the role of phosphorylation. S 2 Show the structure of eukaryotic ribosomes and tRNA molecules. Honors Biology - Today you were working on the app from yesterday to add mutations to RNA. Please follow the instructions I gave you and record your findings tonight. If you were not in class, try this on the left side of your interactive notebook: 1) Write the original amino acid sequence for lactase. Just use the abbreviations (ex. leu, glu, etc.). 2) Create a single deletion mutation and go through steps 1-6 3) Write the sequence of AA for the new protein. 4) How is this new protein different from the original? Now, while we continue exploring how proteins are made, there's something else I want you to consider. Knowing what you know so far, develop a workout and treatment plan for younger (3-9) and older DMD patients(10-20). Address protein synthesis, workout (with rationale), and use of drugs, gene therapy, or CRISPR. This is not a really long essay, it should be a concise essay that is no longer than 1 page front and back. I think you could organize your thinking into an introduction to DMD and the problem with protein synthesis, the next section could be on treatments, the third section could be what is best for young DMd patients, and the last being wht to do with older DMD patients. If you include any information from outside of your notebook, please place it in a bibliography. The final draft will be due on Thursday. This will be graded using the Criterion D rubric, so check that out. I placed it below: The student is able to explain the ways in which science is applied and used to address a specific problem or issue, discuss and evaluate the implications of using science and its application to solve a specific problem or issue, interacting with a factor (moral, environmental, social, technological, ethical, historical), consistently apply scientific language to communicate understanding clearly and precisely, and document sources correctly. Wednesday IB Biology - Hey folks, you worked hard today. Just make sure you are not wasting too much time on your plot and not enough on your content. Other than your paper, which is due tomorrow, you should just work on your movie. You should be planning on being done with your movie by next Wednesday. Oh, one last thing, some of you may be finding this process difficult to understand. If this describes you, try playing this game. It may help with the basic ideas: https://biomanbio.com/HTML5GamesandLabs/LifeChemgames/protsynthracehtml5page.html Honors Biology - Today you collected lots of data on mutated DNA that produced non-functional proteins. This is how people with a gene that isn't coded right can have problems. Remember, proteins make up most of our bodies and do nearly all of our metabolic processes. Tonight I want you to complete your DMD Therapy Recommendation Paper, but also make sure that is in a hard copy ready to be turned in. Do not ask me to print it for you, or I may have to poke you with a sharp stick. Thursday IB Biology - Today you turned in your pro/con paper on treatments for genetic disorders. You were able to get feedback and respond to your work, but I will eventually place the last score on it. Next, you went back to working on projects, but while I have covered most of the important facts, there are other fine points that I would like to clarify with you. Tonight I would like you to respond to the TOK found on page 366. This TOK question asks you to consider how we name things. After reading the prompt, think about the function of why we name things. Which method of naming organelles is best? Provide a rationale for your thinking. Bonus: Can you think of a similar problem in defining ideas/concepts, but from outside of biology? Lastly, DON'T forget to keep pace on completing your video. You should have it all laid out and production should have begun. Honors Biology - Today we finally got a chance to see what our big data looks like. YOu probably noticed that mutations are not a good thing, MOST OF THE TIME. You then reflected back on what we know about DMD patients and how that description pretty much describes the issue with ANY genetic disorder! ...but we still haven't figured out how these disorders get inherited so that will be our next topic. In the meantime, on the left side of the entry on Protein Synthesis, Part 2, I want you to read the article that I have posted mutation causes: https://ghr.nlm.nih.gov/primer/mutationsanddisorders/genemutation There are 6 paragraphs so you should have a minimum of 6 notes, but will probably note more. Come prepared with an understanding of mutation causes. Friday IB Biology - By Monday complete the two DBQs that are found on page 356 and 358. Please also read the following article and give me NO MORE THAN a 3 sentence summary of the major points. https://www.sciencedaily.com/releases/2017/08/170816145357.htm This should be on a separate piece of paper. Honors Biology - Today we reviewed all of the new ideas from last night's article such as polymorphism and mosaicism. Next we moved on to looking at the next big idea of, "HOW do these kid inherit this condition and why is it mostly boys?" We have developed some questions using the science cross cutting concepts to set our direction, but then started to get answers by getting some information from an article. Well, you didn't actually get into the article, you just got it into your notebook. This article should be taped in on the right hand side of a new entry, yes, both sheets, one on top of the other. This weekend I want you to number every paragraph in the article now that it's in your notebook. You should have 17 paragraphs labelled when you are done because I also want you to assign a number (13) to the picture on the final page. If you are the first person in your row, you need to do part 1 of the article. If you sit in seat 2 or 3, you should do part 2, and if you sit in seat 4 or 5, you should do part 3. What do you do? I want you to highlight the important pieces/facts/points in each paragraph. You may NOT highlight more than three things in any one paragraph, and many paragraphs will have only 1 important idea. Monday
IB Biology - Watch this: https://www.youtube.com/watch?v=TNKWgcFPHqw Flow chart/storyboard this process. Be sure to make only 4-6 frames per page. Around these frames you will match the following standards/topics to the work you have done and you will annotate the storyboard you have created. Understandings:
Tonight you should be familiar with these concepts from the book. Feel free to come prepared with questions is you have any confusion: Applications:
Honors Biology - Today you started by looking at each other's analogies. We looked at weaknesses and strengths and then pursued the question of what are the therapies associated with people who have DMD. The five topics were: drugs, stem cells, CRISPR/Cas9, surgery, and Gene therapy. You shared your work with other groups to make your list complete. Tonight you will conclude by coming up with your top three therapies for DMD patients based off of what you know at this point. You must complete this tonight on the left hand side of your entry. Please be sure that you explain why you ranked your top three therapies the way you did. Explanations are where you will receive credit. Tuesday IB Biology - Today we started the day dealing with the questions you had from last night. The big idea was that DNA holds the code to you, and this DNA replicates to accommodate cellular division, but when division occurs the DNA needs to wind up around histones to form nucleosomes, which ultimately show us the chromosome structures we are used to. Here's a video of that last part of the process: https://www.biointeractive.org/classroom-resources/how-dna-packaged Next, we took a virtual reality trip into the cell to take a look at the structures where all of the replication and protein synthesis happen. You actually saw a protein created with mRNA and ribosomes. Here's the vr video for that here: https://www.youtube.com/watch?v=2f4t9nWRITo As we transition into protein synthesis, I want you to prepare by watching the following video and to connect what you find in the pages of 116-122 in your book with what you see. I would take the headings of each of the book sections and then watch the videos and add notes. The following are the two videos. https://dnalc.cshl.edu/view/16933-3D-Animation-of-DNA-to-RNA-to-Protein.html https://www.youtube.com/watch?v=gG7uCskUOrA When you are done you should have a basic understanding of the fundamental steps in transcription, post-transcription modification of the pre-mRNA (or splicing), translation using ribosomes, and protein synthesis. Also read and have a written opinion on the TOK on pg.347 ready to turn in. This should take a short time, but must have support for your stance. Honors Biology - Today we looked at what you had determined what were plausible cures and treatments for DMD, and in the process we learned that to know what happens with people with DMD we need to go to the nucleus where the DNA is stored! We then went on a field trip!!! We watched the following virtual reality video and got a chance to cruise around a cell and find out where this DNA is hiding. Here's the vr video for that here: https://www.youtube.com/watch?v=2f4t9nWRITo Yet in order for us to learn more about how this DNA works we first need to understand in detail what DNA is. This is why we started the POGIL which you will work on tomorrow. Tonight I want you to watch these two videos. They're on CRISPR/Cas9 and should give you some interesting insights as to where we are and how it can be used. Please add appropriate notes to your notes from today. Just open your notebook and watch. You can always write notes in "your crack" if you have run out of room. https://www.youtube.com/watch?v=UKbrwPL3wXE https://www.youtube.com/watch?v=1BXYSGepx7Q Wednesday IB Biology - Today we started by discussing the dilemma of when scientists should reveal their findings, when they have very clear data, or when they have a really good hunch based off of data. There really isn't a really good answer, but I hope you will be open and collaborative when you start your careers. Next we tested ourselves by writing about the whole transcription/translation process. I think a lot of you need to start working on getting this info down. Once you got down whatever you remembered, we exchanged papers. We then started to look at the video from last night and add notes to our partners sheets so they will get a better picture. Tonight I need you to look at the splicing video for post-transcription modification since many of you asked about it. https://dnalc.cshl.edu/view/16938-3D-Animation-of-RNA-Splicing.html Once you are done, please clean up the work your partner did today in class by reviewing the videos from yesterday as well as the following website. Write a positive comment on the paper and have it ready to return. http://www.phschool.com/science/biology_place/biocoach/transcription/premrna.html Tomorrow you have a guest speaker. His name is Dr. Robert Tendick and is a physical therapist. Got any questions for him? Okay, now get one ready! Honors Biology - Today we started with a discussion of last night's work. What a crazy scary idea of what might be done with CRISPR/Cas9 in the future, but let's hope that we can at least figure out how to help some genetic disorders soon. Next, you jumped into the POGIL work on DNA since we need to figure out what this DNA is all about and how can it be affecting people in such a troubling way. We will finish these tomorrow, but in the meantime, I would like you to start a new entry titled: Why don’t people with DMD make dystrophin? This is the very next question we will try to answer. There really isn't any homework at this point so come tomorrow ready to work. If you are curious, watch this video on: Darius Weems ABC News story (8:44) https://www.youtube.com/watch?v=5kMew3lnAAI and/or US research with CRISPR(4:12): https://www.youtube.com/watch?v=RB5WYe_cX_A Feel free to add any notes you like. Thursday IB Biology - Today was a short day and our guest speaker couldn't make it, but whatever, life happens. We on the other hand need to keep moving. What I need you to do is to continue putting the pieces together for your current topic which can be quite complex. Tonight I want you to make ordinary/simple flash cards with a term on one side and a definition on the back side. The terms are as follows: nucleosomes, histones, nucleotides, helicase, primase, polymerase, ligase, exonuclease, spliceosomes, codon, anti-codon, tRNA, mRNA, ribosomal site A (aminoacyl), ribosomal site P (Peptidyl), ribosomal site E (exit) sites, ribosomal subunits, polysomes These should be complete by tomorrow. Honors Biology - Today we finished up the POGIL on DNA. Why you may ask, and the answer you gave me was because the DNA holds the coding for all proteins, like dystrophin. SO what's next? Well, tonight I want you to go onto the right page of the entry you made last night and on the right side I want you to play this game: https://www.biomanbio.com/HTML5GamesandLabs/Genegames/mitosismoverpage.html and take general notes. There will be a quiz on this tomorrow!!! Friday IB Biology - Today we started with clarifying any work that you partner did for you. Next we discussed structure and function of the components involved in the process of building proteins. We talked about codon and anti-codon, etc. Lastly today we then looked at a real life condition attached to this big idea. Not that it happen in transcription and translation, but maybe you can see how the process interacts with coding a little bit better. Here are some videos that can be used. https://www.youtube.com/watch?v=Ebu8W8Osuxk Then I used this picture: https://www.sarepta.com/technology/therapeutic-applications This weekend, I leave your work in your hands. Please check out he powerpoints found on these pages to review everything from chapters 7.2 and 7.3. https://www.bioknowledgy.info/72-transcription-and-gene-expression.html https://www.bioknowledgy.info/73-translation.html Oh, lastly, be sure to add a picture (yes, color) to each of the flash cards. Senior Opportunity!!! The Borrego internship program is currently taking applications. Please share this information with your students and teachers. Borrego Internship Placing it in your Health Pathway google classroom would be ideal. The link can also be found on the GHD website under work based learning. Students accepted into the program have high priority for CPR training. Honors Biology - Today we tried to wrap up all that we did this week with the last bits of information necessary for us to understand how DMD works to cause problems in muscles. Last night you played with a game on mitosis, and got "quizzed" on it. 1) We now know that DMD is genetic, 2) Genes are code for in the DNA of every cell, 3) DNA makes proteins that do all of the function in your body, 4) Replication happens to create an identical copy of your DNA during mitosis whether the gene/DNA is correct or not. This is why people with DMD cannot make dystrophin.Next week we will look at how proteins are made, but until then write the four concepts above in your notes and make sure you know them for Monday, or have questions ready. Monday IB Biology - Today we reviewed the many questions about DNA/RNA structure. You should have a fairly good idea of DNA/RNA's composition and structure, as well as its properties. Tonight I want you to review Chargaff's data by completing the DBQ on page 107. Use COMPLETE and DETAILED sentences for your responses making sure to address the command terms in the question. Please complete this on a separate sheet of paper so it can be turned in. Honors Biology - Before we started our new unit we updated our table of contents, and then boxed our first set of notes in a color and labeled them, "the crawl." To start our new unit you had an opportunity to view a new phenomenon (I have placed a copy below.) We then came to many logical conclusions about what we had seen. After discussing and listing those that we were most sure of, we then discussed what it is we would need to know to find out what is wrong with these subjects and then posted these on the board. Tonight I want you to start to think about these subjects and I want you to identify which body systems are affected and what would be your top 3 choices as to what happened to these kids. Your body systems ideas and top three choices will be written on a SEPARATE SHEET of paper (not in your notebook). Let me remind you to write in complete sentences, and know that you will not receive credit unless you also have an explanation of why you think the conditions you've chosen are possible. HEY, I need to clarify something I said in class today. While debriefing the test I said that the best explanation would be low blood sugar, BUT I was referring to the Crawlers, NOT to the rower. For the rower (the test) you only needed to explain how these were all related to his experience. So, don't freak if you didn't get into detail about blood sugar regulation! Tuesday IB Biology - I blew it yesterday and today! I was suppose to remind you about your PET. Are you still growing it? are you still measuring it? You should take a picture of it again as you will need that to show it's development. Be sure you are getting all of the measurements. Beyond your pet (like there's anything more important?), I need you to start to prepare for the unit exam. I have provided an outline of every Understanding, Application, and Skill listed for the chapters we have covered. Please use it tonight to take inventory on yourself. Which pieces are solid in your mind, which are not so strong. Tomorrow we will review all of these for you, but come prepared otherwise I don't really have any sympathy for you. The big test is on Thursday and Friday. Honors Biology - Today we started by looking at your ideas about what is wrong with our disabled kids, and then went back to our ideas from yesterday in order to establish some questions about what we are going to pursue. You set up a new entry on How Muscles Work and watched the following video to take notes: https://www.youtube.com/watch?v=94Q-fvCAJzQ Tonight I want you to add to your notes by drawing a healthy bicep muscle including tendons. Also show the muscle's layers: fascicle, muscle fiber, myofibrils, and actin and myosin) like you saw in the video. I've also placed an image that should really help as well on the bottom of this page. Now, On the left hand side of your entry from today, I want you to draw that same picture from the right hand side, but with the addition of what must be different in these disabled boys. The difference could be on the very tiny scale or an overall problem, but be sure to draw in detail and explain what you drew! ...Yes, color is always necessary for credit. Wednesday IB Biology - Today we spent time answering all of your questions on the test. You can still come see me at any time before the test to get help, but you should be fairly solid to take the test tomorrow. BUT don't forget that you have a number of flashcards that you could also be using as a review, and of course your book. Please review everything as there are no retakes. Honors Biology - Today was an amazing brain storming session that I didn't really expect to happen the way it did. You have now isolated that the condition these kids have in a muscular dystrophy of some sort and that it is genetically related. WOW! I am super impressed. Tonight I want you to read the following article and we'll see if you are right. For this article I want you to use the reading strategy of "Sum It Up" on the right hand side of a new entry. On the left hand side please be sure to recreate the lower diagram from the article. We will use this tomorrow so don't use more than 1/2 of a page. The article can be found below. Oh, and if you want to learn some more about the muscles in your body, play this game and let me know how well you did: http://www.anatomyarcade.com/games/PAM/PAM.html Thursday IB Biology - Today we took the first part of your unit exam and tomorrow you will take the second part. The second part is very much like paper 3 on the IB exam so it will be composed of a number of graphs that will need to be interpreted. Please be sure that you look over the following website for guidance on reading graphs. Oh, and yes, the content is still on your knowledge of macromolecules. https://www.thinkib.net/biology/page/19051/describing-trends-in-ib-graphs Honors Biology - Today you guys were able to describe actin, myosin, titin, and dystrophin from your readings. These are all very important proteins to muscle tissue, but what exactly is this "protein" thing and how does it fit into the big picture of what we are made of? This is why we went to the idea of looking at macromolecules. So I gave you that sheet today (attached below) and then gave you important information on the function of each of these. Tonight I want you to read the following article on why muscles don't work as well in DMD patients. (found below) Once you read the article I want you to submit your responses to the article on the following google form: https://forms.gle/y4dtE3mgnxmeNvKT9 Nothing needs to be written in your notebook unless you would like to add some "tasty tidbits" to your notes. Friday IB Biology - Today you did part two of our unit exam. I hope you feel like you did well. WHile we will start a new course of study going into details about protein synthesis on Monday, this weekend I'm not assigning homework. If you chose to work as an individual on redoing any part of your lab, this is the time to do it. If you return your new revised copy along with the original paper, you will be eligible to raise your grade. Please consider doing this as this may be the only time you are allowed to do this. Honors Biology - So today we spent a chunk of our time digging into the idea of WHY. Why do people with DMD have this problem with their muscles. You learned about dystrophins role in the cell and what it means to have Creatine Kinases (CK) in your blood. This weekend I want you finish watching the video (5min) and taking notes on the right side of our entry. On the left I want you to come up with a visual analogy for dystrophin and it's role within cells. An example of this would be looking at dystrophin being like and anchor on a boat. ....BUT you need to come up with something different than an anchor and boat. Yes, you should use neat lines, labels, and of course, COLOR. A brief explanation (3-4 sentences) should be below your picture should describe why your visual analogy is a an accurate one. You will be sharing these on Monday. Video on DMD: https://www.youtube.com/watch?v=Ebu8W8Osuxk
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