classwork/Homework
Monday
IB Biology - Today we reviewed how we should approach TOKs in the future, and then checked off your flash cards for completion. Lastly, I gave you the criteria (A and D) for your project on protein synthesis (2.7, 7.1, 7.2 and 7.3). Tonight you need to go through all of your flashcards, but only once or twice. Make sure you are sticking those terms in your head. Second I need you to start a storyboard with your partners. A shared google slides presentation would work well. In the notes section you could make sure you account for everything you need to have in your presentation Honors Biology - Here's the link to the simulation we played with today. http://genes.inquiry-hub.net You should have started the process of understanding Protein Synthesis, but we still have a long way to go. From the steps you learned about today, I want you to watch the following video (https://www.youtube.com/watch?v=Vm3MWy3lY4Q) and write the narrative for what is going on in the video and how it matches the simulation that we played with today. In other words, add text to the observations we made in class. This goes on the bottom of the right hand page we started today. Tuesday IB Biology - So today is the first real work day for this project. and I have posted every bit of information you could possibly need to know for this movie below. Please cut and paste these into your google slides. You can move them around into your story board, but eventually you will share these with me so I can assess you work. I believe all of this will be due next Wednesday, but that may change as we get closer to the date. Tonight you should have a rough framework of your scenes and which standards they will address. The second thing I would suggest is that you take another run through your flash cards tonight. Don't forget about the old cards either as there will be questions on our second unit exam from the past. Lastly, I want you to start your outline of a criteria D project, a reflection on the use of CRISPR, Gene Therapy, and drug therapies that work on post transcription modification on people with genetic disorders such as DMD, or Cystic Fibrosis, or ??? This is a pro and con paper with your evaluation at the end. Be thorough in your discussion. No more than one sheet of paper front and back. This will be due on Thursday. Here's the criterion D top descriptor: The student is able to explain the ways in which science is applied and used to address a specific problem or issue, discuss and evaluate the implications of using science and its application to solve a specific problem or issue, interacting with a factor (moral, environmental, social, technological, ethical, historical), consistently apply scientific language to communicate understanding clearly and precisely, and document sources correctly. 7.1 DNA Structure and Replication Essential Idea: The structure of DNA is ideally suited to its function. U 1 Nucleosomes help to supercoil the DNA. U 2 DNA structure suggested a mechanism for DNA replication. U 3 DNA polymerases can only add nucleotides to the 3’ end of a primer. U 4-5 DNA replication is continuous on the leading strand and discontinuous on the lagging strand, and carried out by a complex system of enzymes. U 6 Some regions of DNA do not code for proteins but have other important functions. Such as ??? A 1 Rosalind Franklin and Maurice Wilkins’ investigation of DNA structures by X-ray diffraction. A 2 Use of nucleotides containing dideoxyrubonucleic acid to stop DNA replication in preparation of samples for base sequencing. A 3 Tandem repeats (VNTR) are used in DNA profiling. S 1 Analysis of results of the Hershey and Chase experiment providing evidence that DNA is the genetic material. NOS 1 Making careful observations-Rosalind Franklin’s X-ray diffraction provided crucial evidence that DNA is a double helix. 7.2 Transcription and Gene Expression Essential Idea: Information stored as a code in DNA is copied into mRNA. U 1 Transcription occurs in a 5’ to 3’ direction. U 2 Nucleosomes help to regulate transcription in eukaryotes. U 3 Eukaryotic cells modify mRNA after transcription. U 4 Splicing of mRNA increases the number of different proteins an organism can produce. U 5 Gene expression is regulated by proteins that bind to specific base sequences in DNA. U 6 The environment of a cell and of an organism has an impact on gene expression. A 1 The promoter as an example of non-coding DNA with a function. Or you could use Telomeres. S 1 Analysis of changes in the DNA methylation patterns. NOS 1 Noticing patterns, trends and discrepancies- there is mounting evidence that the environment can trigger heritable changes in epigenetic factors. 7.3 Translation Essential Idea: Information transferred from DNA to mRNA is translated into an amino acid sequence. U 1 Initiation of translation involves assembly of the components that carry out the process. U 2 Synthesis of the polypeptide involves a repeated cycle of events. U 3 Disassembly of the components follows termination of translation. U 4-5 Free ribosomes synthesize proteins primarily for secretion or use in lysosomes, and bound ribosomes synthesize proteins for use primarily within the cell. U 6 Translation can occur immediately after transcription in prokaryotes due to the absence of a nuclear membrane, but not in eukaryotes. U 7-10 The sequence and number of amino acids in the polypeptide is the primary structure. The secondary structure is the formation of alpha helices and beta pleated sheets stabilized by hydrogen bonding. The tertiary structure is the further folding of the polypeptide stabilized by interactions between R groups. The quaternary structure exists in proteins with more than one polypeptide chain. A 1 tRNA-activating enzymes illustrate enzyme-substrate specificity and the role of phosphorylation. S 2 Show the structure of eukaryotic ribosomes and tRNA molecules. Honors Biology - Today you were working on the app from yesterday to add mutations to RNA. Please follow the instructions I gave you and record your findings tonight. If you were not in class, try this on the left side of your interactive notebook: 1) Write the original amino acid sequence for lactase. Just use the abbreviations (ex. leu, glu, etc.). 2) Create a single deletion mutation and go through steps 1-6 3) Write the sequence of AA for the new protein. 4) How is this new protein different from the original? Now, while we continue exploring how proteins are made, there's something else I want you to consider. Knowing what you know so far, develop a workout and treatment plan for younger (3-9) and older DMD patients(10-20). Address protein synthesis, workout (with rationale), and use of drugs, gene therapy, or CRISPR. This is not a really long essay, it should be a concise essay that is no longer than 1 page front and back. I think you could organize your thinking into an introduction to DMD and the problem with protein synthesis, the next section could be on treatments, the third section could be what is best for young DMd patients, and the last being wht to do with older DMD patients. If you include any information from outside of your notebook, please place it in a bibliography. The final draft will be due on Thursday. This will be graded using the Criterion D rubric, so check that out. I placed it below: The student is able to explain the ways in which science is applied and used to address a specific problem or issue, discuss and evaluate the implications of using science and its application to solve a specific problem or issue, interacting with a factor (moral, environmental, social, technological, ethical, historical), consistently apply scientific language to communicate understanding clearly and precisely, and document sources correctly. Wednesday IB Biology - Hey folks, you worked hard today. Just make sure you are not wasting too much time on your plot and not enough on your content. Other than your paper, which is due tomorrow, you should just work on your movie. You should be planning on being done with your movie by next Wednesday. Oh, one last thing, some of you may be finding this process difficult to understand. If this describes you, try playing this game. It may help with the basic ideas: https://biomanbio.com/HTML5GamesandLabs/LifeChemgames/protsynthracehtml5page.html Honors Biology - Today you collected lots of data on mutated DNA that produced non-functional proteins. This is how people with a gene that isn't coded right can have problems. Remember, proteins make up most of our bodies and do nearly all of our metabolic processes. Tonight I want you to complete your DMD Therapy Recommendation Paper, but also make sure that is in a hard copy ready to be turned in. Do not ask me to print it for you, or I may have to poke you with a sharp stick. Thursday IB Biology - Today you turned in your pro/con paper on treatments for genetic disorders. You were able to get feedback and respond to your work, but I will eventually place the last score on it. Next, you went back to working on projects, but while I have covered most of the important facts, there are other fine points that I would like to clarify with you. Tonight I would like you to respond to the TOK found on page 366. This TOK question asks you to consider how we name things. After reading the prompt, think about the function of why we name things. Which method of naming organelles is best? Provide a rationale for your thinking. Bonus: Can you think of a similar problem in defining ideas/concepts, but from outside of biology? Lastly, DON'T forget to keep pace on completing your video. You should have it all laid out and production should have begun. Honors Biology - Today we finally got a chance to see what our big data looks like. YOu probably noticed that mutations are not a good thing, MOST OF THE TIME. You then reflected back on what we know about DMD patients and how that description pretty much describes the issue with ANY genetic disorder! ...but we still haven't figured out how these disorders get inherited so that will be our next topic. In the meantime, on the left side of the entry on Protein Synthesis, Part 2, I want you to read the article that I have posted mutation causes: https://ghr.nlm.nih.gov/primer/mutationsanddisorders/genemutation There are 6 paragraphs so you should have a minimum of 6 notes, but will probably note more. Come prepared with an understanding of mutation causes. Friday IB Biology - By Monday complete the two DBQs that are found on page 356 and 358. Please also read the following article and give me NO MORE THAN a 3 sentence summary of the major points. https://www.sciencedaily.com/releases/2017/08/170816145357.htm This should be on a separate piece of paper. Honors Biology - Today we reviewed all of the new ideas from last night's article such as polymorphism and mosaicism. Next we moved on to looking at the next big idea of, "HOW do these kid inherit this condition and why is it mostly boys?" We have developed some questions using the science cross cutting concepts to set our direction, but then started to get answers by getting some information from an article. Well, you didn't actually get into the article, you just got it into your notebook. This article should be taped in on the right hand side of a new entry, yes, both sheets, one on top of the other. This weekend I want you to number every paragraph in the article now that it's in your notebook. You should have 17 paragraphs labelled when you are done because I also want you to assign a number (13) to the picture on the final page. If you are the first person in your row, you need to do part 1 of the article. If you sit in seat 2 or 3, you should do part 2, and if you sit in seat 4 or 5, you should do part 3. What do you do? I want you to highlight the important pieces/facts/points in each paragraph. You may NOT highlight more than three things in any one paragraph, and many paragraphs will have only 1 important idea.
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