classwork/Homework
Monday
IB Biology - Watch this: https://www.youtube.com/watch?v=TNKWgcFPHqw Flow chart/storyboard this process. Be sure to make only 4-6 frames per page. Around these frames you will match the following standards/topics to the work you have done and you will annotate the storyboard you have created. Understandings:
Tonight you should be familiar with these concepts from the book. Feel free to come prepared with questions is you have any confusion: Applications:
Honors Biology - Today you started by looking at each other's analogies. We looked at weaknesses and strengths and then pursued the question of what are the therapies associated with people who have DMD. The five topics were: drugs, stem cells, CRISPR/Cas9, surgery, and Gene therapy. You shared your work with other groups to make your list complete. Tonight you will conclude by coming up with your top three therapies for DMD patients based off of what you know at this point. You must complete this tonight on the left hand side of your entry. Please be sure that you explain why you ranked your top three therapies the way you did. Explanations are where you will receive credit. Tuesday IB Biology - Today we started the day dealing with the questions you had from last night. The big idea was that DNA holds the code to you, and this DNA replicates to accommodate cellular division, but when division occurs the DNA needs to wind up around histones to form nucleosomes, which ultimately show us the chromosome structures we are used to. Here's a video of that last part of the process: https://www.biointeractive.org/classroom-resources/how-dna-packaged Next, we took a virtual reality trip into the cell to take a look at the structures where all of the replication and protein synthesis happen. You actually saw a protein created with mRNA and ribosomes. Here's the vr video for that here: https://www.youtube.com/watch?v=2f4t9nWRITo As we transition into protein synthesis, I want you to prepare by watching the following video and to connect what you find in the pages of 116-122 in your book with what you see. I would take the headings of each of the book sections and then watch the videos and add notes. The following are the two videos. https://dnalc.cshl.edu/view/16933-3D-Animation-of-DNA-to-RNA-to-Protein.html https://www.youtube.com/watch?v=gG7uCskUOrA When you are done you should have a basic understanding of the fundamental steps in transcription, post-transcription modification of the pre-mRNA (or splicing), translation using ribosomes, and protein synthesis. Also read and have a written opinion on the TOK on pg.347 ready to turn in. This should take a short time, but must have support for your stance. Honors Biology - Today we looked at what you had determined what were plausible cures and treatments for DMD, and in the process we learned that to know what happens with people with DMD we need to go to the nucleus where the DNA is stored! We then went on a field trip!!! We watched the following virtual reality video and got a chance to cruise around a cell and find out where this DNA is hiding. Here's the vr video for that here: https://www.youtube.com/watch?v=2f4t9nWRITo Yet in order for us to learn more about how this DNA works we first need to understand in detail what DNA is. This is why we started the POGIL which you will work on tomorrow. Tonight I want you to watch these two videos. They're on CRISPR/Cas9 and should give you some interesting insights as to where we are and how it can be used. Please add appropriate notes to your notes from today. Just open your notebook and watch. You can always write notes in "your crack" if you have run out of room. https://www.youtube.com/watch?v=UKbrwPL3wXE https://www.youtube.com/watch?v=1BXYSGepx7Q Wednesday IB Biology - Today we started by discussing the dilemma of when scientists should reveal their findings, when they have very clear data, or when they have a really good hunch based off of data. There really isn't a really good answer, but I hope you will be open and collaborative when you start your careers. Next we tested ourselves by writing about the whole transcription/translation process. I think a lot of you need to start working on getting this info down. Once you got down whatever you remembered, we exchanged papers. We then started to look at the video from last night and add notes to our partners sheets so they will get a better picture. Tonight I need you to look at the splicing video for post-transcription modification since many of you asked about it. https://dnalc.cshl.edu/view/16938-3D-Animation-of-RNA-Splicing.html Once you are done, please clean up the work your partner did today in class by reviewing the videos from yesterday as well as the following website. Write a positive comment on the paper and have it ready to return. http://www.phschool.com/science/biology_place/biocoach/transcription/premrna.html Tomorrow you have a guest speaker. His name is Dr. Robert Tendick and is a physical therapist. Got any questions for him? Okay, now get one ready! Honors Biology - Today we started with a discussion of last night's work. What a crazy scary idea of what might be done with CRISPR/Cas9 in the future, but let's hope that we can at least figure out how to help some genetic disorders soon. Next, you jumped into the POGIL work on DNA since we need to figure out what this DNA is all about and how can it be affecting people in such a troubling way. We will finish these tomorrow, but in the meantime, I would like you to start a new entry titled: Why don’t people with DMD make dystrophin? This is the very next question we will try to answer. There really isn't any homework at this point so come tomorrow ready to work. If you are curious, watch this video on: Darius Weems ABC News story (8:44) https://www.youtube.com/watch?v=5kMew3lnAAI and/or US research with CRISPR(4:12): https://www.youtube.com/watch?v=RB5WYe_cX_A Feel free to add any notes you like. Thursday IB Biology - Today was a short day and our guest speaker couldn't make it, but whatever, life happens. We on the other hand need to keep moving. What I need you to do is to continue putting the pieces together for your current topic which can be quite complex. Tonight I want you to make ordinary/simple flash cards with a term on one side and a definition on the back side. The terms are as follows: nucleosomes, histones, nucleotides, helicase, primase, polymerase, ligase, exonuclease, spliceosomes, codon, anti-codon, tRNA, mRNA, ribosomal site A (aminoacyl), ribosomal site P (Peptidyl), ribosomal site E (exit) sites, ribosomal subunits, polysomes These should be complete by tomorrow. Honors Biology - Today we finished up the POGIL on DNA. Why you may ask, and the answer you gave me was because the DNA holds the coding for all proteins, like dystrophin. SO what's next? Well, tonight I want you to go onto the right page of the entry you made last night and on the right side I want you to play this game: https://www.biomanbio.com/HTML5GamesandLabs/Genegames/mitosismoverpage.html and take general notes. There will be a quiz on this tomorrow!!! Friday IB Biology - Today we started with clarifying any work that you partner did for you. Next we discussed structure and function of the components involved in the process of building proteins. We talked about codon and anti-codon, etc. Lastly today we then looked at a real life condition attached to this big idea. Not that it happen in transcription and translation, but maybe you can see how the process interacts with coding a little bit better. Here are some videos that can be used. https://www.youtube.com/watch?v=Ebu8W8Osuxk Then I used this picture: https://www.sarepta.com/technology/therapeutic-applications This weekend, I leave your work in your hands. Please check out he powerpoints found on these pages to review everything from chapters 7.2 and 7.3. https://www.bioknowledgy.info/72-transcription-and-gene-expression.html https://www.bioknowledgy.info/73-translation.html Oh, lastly, be sure to add a picture (yes, color) to each of the flash cards. Senior Opportunity!!! The Borrego internship program is currently taking applications. Please share this information with your students and teachers. Borrego Internship Placing it in your Health Pathway google classroom would be ideal. The link can also be found on the GHD website under work based learning. Students accepted into the program have high priority for CPR training. Honors Biology - Today we tried to wrap up all that we did this week with the last bits of information necessary for us to understand how DMD works to cause problems in muscles. Last night you played with a game on mitosis, and got "quizzed" on it. 1) We now know that DMD is genetic, 2) Genes are code for in the DNA of every cell, 3) DNA makes proteins that do all of the function in your body, 4) Replication happens to create an identical copy of your DNA during mitosis whether the gene/DNA is correct or not. This is why people with DMD cannot make dystrophin.Next week we will look at how proteins are made, but until then write the four concepts above in your notes and make sure you know them for Monday, or have questions ready.
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